Mechanism for RNA splicing of gene transcripts
نویسندگان
چکیده
منابع مشابه
Mechanism for RNA splicing of gene transcripts.
It has been demonstrated that structural genes in eukaryotes contain intervening sequences (introns) which are absent from expressed sequences (exons) [l-6]. There is evidence that intervening sequences are transcribed [7], but subsequently the introns are removed by a process which is now known as RNA splicing [ 8,9]. RNA splicing must be a very precise process since it results in the joining ...
متن کاملAlternative Splicing and Extensive RNA Editing of Human TPH2 Transcripts
Brain serotonin (5-HT) neurotransmission plays a key role in the regulation of mood and has been implicated in a variety of neuropsychiatric conditions. Tryptophan hydroxylase (TPH) is the rate-limiting enzyme in the biosynthesis of 5-HT. Recently, we discovered a second TPH isoform (TPH2) in vertebrates, including man, which is predominantly expressed in brain, while the previously known TPH i...
متن کاملRNA-Seq analysis of splicing in Plasmodium falciparum uncovers new splice junctions, alternative splicing and splicing of antisense transcripts
Over 50% of genes in Plasmodium falciparum, the deadliest human malaria parasite, contain predicted introns, yet experimental characterization of splicing in this organism remains incomplete. We present here a transcriptome-wide characterization of intraerythrocytic splicing events, as captured by RNA-Seq data from four timepoints of a single highly synchronous culture. Gene model-independent a...
متن کاملTwo novel transcripts for human endothelin B receptor produced by RNA editing/alternative splicing from a single gene.
Hirschsprung disease is a heterogeneous genetic disorder, causative genes of which include the endothelin B receptor (ETB). To investigate the mutations of ETB in Hirschsprung disease, expression of the ETB gene in lymphoblastoid cells from patients and normal healthy adults was examined, and novel mutant transcripts were found. The mutant ETB gene transcripts lacked a 134-bp nucleotide sequenc...
متن کاملMoving beyond gene expression: identification of lung-disease-associated novel transcripts and alternative splicing by RNA sequencing
Moving beyond gene expression: identification of lung-disease-associated novel transcripts and alternative splicing by RNA sequencing John Brothers II, Rebecca Kusko, Gang Liu, Lingqi Luo, Brenda Juan Guardela, John Tedrow, Yuriy Alekesyev, Ivana V Yang, Mick Correll, Mark Geraci, John Quackenbush, Frank Sciurba, Paola Sebastiani, Marc Lenburg, Naftali Kaminski, David A Schwartz, Avrum Spira, J...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: FEBS Letters
سال: 1979
ISSN: 0014-5793
DOI: 10.1016/0014-5793(79)80682-1